Performance Analysis of Maximal-Ratio Combining and Space-Time Block Codes with Transmit Antenna Selection over Nakagami-m Fading Channels

The latest wireless communication techniques such as highspeed wireless internet application demand higher data rates and better quality of service (QoS). However, transmission reliability is still degraded by harsh propagation channels. Multiple-input multiple-output (MIMO) systems can increase the system capacity and improve transmission reliability. By transmitting multiple copies of data, a MIMO system can effectively combat the effects of fading. Due to the high hardware cost of a MIMO system, antenna selection techniques have been applied in MIMO system design to reduce the system complexity and cost. The Nakagami-m distribution has been considered for MIMO channel modeling since a wide range of fading channels, from severe to moderate, can be modeled by using Nakagami-m distribution. The Rayleigh distribution is a special case of the Nakagami-m distribution. In this thesis, we analyze the error performance of two MIMO schemes: maximal-ratio combining with transmit antenna selection (the TAS/MRC scheme) and space-time block codes with transmit antenna selection (the TAS/STBC scheme) over Nakagami-m fading channels. In the TAS/MRC scheme, one of multiple transmit antennas, which maximizes the total received signal-to-noise ratio (SNR), is selected for uncoded data transmission. First we use a moment generating function based (MGF-based) approach to derive the bit error rate (BER) expressions for binary phase shift keying (BPSK), the symbol error rate (SER) expressions for M-ray phase shift keying (MPSK) and M-ray quadrature amplitude modulation (MQAM) of the TAS/MRC scheme over Nakagami-m fading channels with arbitrary and integer fading parameters m. The asymptotic performance is also investigated. It is revealed that the asymptotic diversity order is equal to the product of the Nakagami fading parameter m, the number of transmit antenna Lt and the number of receive antenna Lr as if all transmit antenna were used. Then a Gaussian Q-functions approach is used to investigate the error performance of the TAS/STBC scheme over Nakagami-m fading channels. In the TAS/STBC scheme, two transmit antennas, which maximize the output SNR, are selected for transmission. The exact and asymptotic BER expressions for BPSK are obtained for the TAS/STBC schemes with three and four transmit antennas. It is shown that the TAS/STBC scheme can provide a full diversity order of mLtLr

Identification and Profiling of MicroRNAs from Skeletal Muscle of the Common Carp

The common carp is one of the most important cultivated species in the world of freshwater aquaculture. The cultivation of this species is particularly productive due to its high skeletal muscle mass; however, the molecular mechanisms of skeletal muscle development in the common carp remain unknown. It has been shown that a class of non-coding ∼22 nucleotide RNAs called microRNAs (miRNAs) play important roles in vertebrate development. They regulate gene expression through sequence-specific interactions with the 3′ untranslated regions (UTRs) of target mRNAs and thereby cause translational repression or mRNA destabilization. Intriguingly, the role of miRNAs in the skeletal muscle development of the common carp remains unknown. In this study, a small-RNA cDNA library was constructed from the skeletal muscle of the common carp, and Solexa sequencing technology was used to perform high throughput sequencing of the library. Subsequent bioinformatics analysis identified 188 conserved miRNAs and 7 novel miRNAs in the carp skeletal muscle. The miRNA expression profiling showed that, miR-1, miR-133a-3p, and miR-206 were specifically expressed in muscle-containing organs, and that miR-1, miR-21, miR-26a, miR-27a, miR-133a-3p, miR-206, miR-214 and miR-222 were differentially expressed in the process of skeletal muscle development of the common carp. This study provides a first identification and profiling of miRNAs related to the muscle biology of the common carp. Their identification could provide clues leading towards a better understanding of the molecular mechanisms of carp skeletal muscle development

A novel rat model of blast-induced traumatic brain injury simulating different damage degree: implications for morphological, neurological, and biomarker changes

In current military conflicts and civilian terrorism, blast-induced traumatic brain injury (bTBI) is the primary cause of neurotrauma. However, the effects and mechanisms of bTBI are poorly understood. Although previous researchers have made significant contributions to establishing animal models for the simulation of bTBI, the precision and controllability of blast-induced injury in animal models must be improved. Therefore, we established a novel rat model to simulate blast-wave injury to the brain. To simulate different extents of bTBI injury, the animals were divided into moderate and severe injury groups. The miniature spherical explosives (PETN) used in each group were of different sizes (2.5 mm diameter in the moderate injury group and 3.0 mm diameter in the severe injury group). A specially designed apparatus was able to precisely adjust the positions of the miniature explosives and create eight rats with bTBI simultaneously, using a single electric detonator. Neurological functions, gross pathologies, histopathological changes and the expression levels of various biomarkers were examined after the explosion. Compared with the moderate injury group, there were significantly more neurological dysfunctions, cortical contusions, intraparenchymal hemorrhages, cortical expression of S-100β, MBP, NSE, IL-8, IL-10, iNOS and HIF-1α in the severe injury group. These results demonstrate that we have created a reliable and reproducible bTBI model in rats. This model will be helpful for studying the mechanisms of bTBI and developing strategies for clinical bTBI treatment